An Electrochemical Method to Detect Gamma Glutamyl Transpeptidase

An Electrochemical Method to Detect Gamma Glutamyl Transpeptidase

Gamma glutamyl transpeptidase (GGT) is a transferase, which is of great importance in sustaining intracellular cysteine and glutathione levels. The abnormal expression of GGT is significantly associated with features of many metabolic syndromes (e.g., hepatocellular carcinoma). Therefore, it is essential to develop methods to detect GGT so as to monitor the physiological or pathological phenome...

Gamma-glutamyl transpeptidase in cancer diagnosis.

Serum gamma-glutamyl transpeptidase ( G G T ), alkaline phosphatase (A L P ) and aspartate aminotransferase (A ST) were assayed in patients with cancer. GGT was more sensitive than either ALP or AST in detecting metastatic car­ cinoma to the liver in both icteric and anicteric patients with cancer. Extremely high activities of GGT were seen in patients with hepatoma, carcinoma of the pancreas a...

Gamma-glutamyl transpeptidase--its role in hepatocarcinogenesis.

Introduction The enzyme gamma-glutamyl transpeptidase (GGT)* is widely used as a marker in preneoplastic lesions in the liver during chemical carcinogenesis (1). The discovery of a link between GGT and liver carcinogenesis first occurred in 1972 when Fiala and co-workers reported elevated levels of the enzyme in livers of rats fed the hepatocarcinogen 3'-methyl-4dimethylaminoazobenzene and also...

Gamma-glutamyl-transpeptidase in myocardial infarction. Clinical and experimental studies.

Gamma-glutamyl Transpeptidase Activity in Human Fetal Lung-derived Cells

Gamma-glutamyl transpeptidase (GGT, EC 2.3.2.2) a membrane-associated enzyme is a main regulator of glutathione (GSH) levels. The enzyme is not only the inhibitor of apoptosis induced by oxidative stress, but it is engaged in anti-tumor drug cell resistance and is considered as a marker for neoplastic changes, cell differentiation and aging. The surface and total activities of GGT in unfixed, f...